J-upscaling in two-dimensional solid-state NMR spectroscopy

J-upscaling in two-dimensional solid-state NMR spectroscopy

Blog Article

The direct measurement of homonuclear scalar couplings (J) in solids, which serve as important parameters for HERAMARE VEG BROTH LOW SODIU the elucidation of molecular structure/ characterization of materials, is difficult due to the inherent broadening of spectral lines in the solid-state NMR.The earlier reported J-measurements in solid-state NMR are based on 1D/ pseudo 2D spin echo modulation techniques, which rely on computing the J-values by fitting the spin-echo modulations to appropriate mathematical functions, and may involve expertise in the area.On the other hand, the present study demonstrates two simple 2D-NMR methods: J-upscaled mechanism uniform cross-peak double quantum filtered COSY (JS-UC2QFCOSY) and its selective refocusing variant JS2-UC2QFCOSY that allow an easy quantification of scalar couplings, which have been exemplified for unambiguous measurement of JCC values in 13C3-alanine and 13C6-histidine.2HCl samples.These versatile experimental approaches are expected to be Libarary highly useful in structural characterizations of organic solids and other materials.